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The Aesthetic Surgery Education and Research Foundation

Physician Initiated Research
BBL Safety and Florida Legislature: What You Should Know, How You Can Help Print
Video Roundtable 

Jeffrey M Kenkel, MD, FACS, Max Polo, MD, Pat Pazmiño, MD, Onelio Garcia Jr, MD  

Aesthetic Surgery Journal Open Forum, ojad041, https://doi.org/10.1093/asjof/ojad041
Published: 06 May 2023

>> View on the Aesthetic Surgery Journal Open Forum Website
 
CD30 Regulation of IL-13–STAT6 Pathway in Breast Implant–Associated Anaplastic Large Cell Lymphoma Print
Marshall E Kadin, MD, John Morgan, PhD, Wei Wei, PhD, Zhihui Song, PhD, Yibin Yang, PhD

Aesthetic Surgery Journal, Volume 43, Issue 2, February 2023, Pages 137–146

Background: Breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a rare, usually indolent CD30+ T-cell lymphoma with tumor cells, often surrounded by eosinophils, expressing IL-13 and pSTAT6.

Objectives: The aim of this study was to understand the unique tumor pathology and growth regulation of BIA-ALCL, leading to potential targeted therapies.

>> View on the Aesthetic Surgery Journal  Website

 
Evaluation of Breast Implant–Associated Anaplastic Large Cell Lymphoma With Whole Exome and Genome Sequencing Print
Neha Akkad, MD, Rohan Kodgule, MD, Eric J Duncavage, MD, Neha Mehta-Shah, MD, MSCI, David H Spencer, MD, PhD, Marcus Watkins, PhD, Cara Shirai, PhD, Terence M Myckatyn, MD, FACS, FRCSC

Aesthetic Surgery Journal, sjac282

Background: Breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy originating from the periprosthetic capsule of a textured, most often macrotextured, breast implant. Identified in women whose indications for breast implants can be either aesthetic or reconstructive, the genomic underpinnings of this disease are only beginning to be elucidated.

Objectives: The aim of this study was to evaluate the exomes, and in some cases the entire genome, of patients with BIA-ALCL. Specific attention was paid to copy number alterations, chromosomal translocations, and other genomic abnormalities overrepresented in patients with BIA-ALCL.  

>> View on the Aesthetic Surgery Journal  Website
 
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