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The Aesthetic Surgery Education and Research Foundation

Physician Initiated Research
Non-Malignant CD30+ Cells in Contralateral Peri-Implant Capsule of Patient With BIA-ALCL: A Premalignant Step? Print

Marshall E. Kadin, MD; Haiying Xu, BA; Lisa M. Hunsicker, MD; and Yingjie Guan, MD, PhD

Aesthetic Surgery Journal
, sjab215

Background: CD30 lymphocyte activation antigen and phosphorylated STAT3 (pSTAT3) are consistent markers of tumor cells in breast implant–associated anaplastic large cell lymphoma (BIA-ALCL). We present a case of BIA-ALCL in a breast implant capsule containing clustered tumor cells expressing CD30, pSTAT3, pSTAT6, interleukin 9, and granzyme B tumor cell biomarkers. Remarkably, the contralateral breast contained many scattered large, atypical CD30+ cells surrounded by inflammatory cells, raising a suspicion of bilateral BIA-ALCL, known to occur in some patients. To clarify the diagnosis, immunohistochemistry and multilabel immunofluorescence were performed. Unlike the tumor cells, the atypical CD30+ cells of the contralateral breast lacked pSTAT3, pSTAT6, interleukin 9, and granzyme B, eliminating a diagnosis of bilateral BIA-ALCL. This case highlights the importance of interpreting CD30 staining in the context of other tumor cell biomarkers and histopathology to avoid an incorrect diagnosis of BIA-ALCL. We believe the findings also suggest the possibility of CD30 expression as an early event in the multistep pathogenesis of BIA-ALCL.

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Granzyme B Is a Biomarker for Suspicion of Malignant Seromas Around Breast Implants Print

Marshall E Kadin, MD, John Morgan, PhD, Haiying Xu, BS, Caroline Glicksman, MD, David Sieber, MD, William P Adams, Jr, MD, Pat McGuire, MD, Mark W Clemens, MD, Archana Thakur, PhD, Lawrence G Lum, MD, DSc

Aesthetic Surgery Journal, sjaa302

Background: Granzyme B (GrB) is a serine protease secreted, along with pore-forming perforin, by cytotoxic lymphocytes to mediate apoptosis in target cells. GrB has been detected in tumor cells associated with systemic and breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) but its potential use for detection of early BIA-ALCL has not been fully investigated.

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Aesthetic Surgery in Plastic Surgery Academia Print

Galen Perdikis, MD, Felmont F Eaves, III, MD, Gabriella E Glassman, BS, Sallie Walker, MSHA, MBA, Li-Ching Huang, PhD, Bruce Mast, MD, Lynn Damitz, MD, J Peter Rubin, MD, Joseph M Serletti, MD, Juliana Hansen, MD, John Potochny, MD, Jeffery Kenkel, MD, Peter J Taub, MD, Sara Sobczyk, MHA, Robert H Gilman, MD, DMD, Michel Hector Saint-Cyr, MD, Paul Cederna, MD

Aesthetic Surgery Journal, sjaa181

Background: Aesthetic surgery is a critical component of academic plastic surgery. As institutions are placing increased focus on aesthetic surgery, there is an opportunity to identify factors that facilitate the creation and maintenance of successful aesthetic plastic surgery programs.

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Modesto, CA
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“…because there are so many important areas of plastic surgery research that need further or ongoing support to help improve our specialty.”

The Aesthetic Society


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