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The Aesthetic Surgery Education and Research Foundation

Evaluation of Breast Implant–Associated Anaplastic Large Cell Lymphoma With Whole Exome and Genome Sequencing Print
Neha Akkad, MD, Rohan Kodgule, MD, Eric J Duncavage, MD, Neha Mehta-Shah, MD, MSCI, David H Spencer, MD, PhD, Marcus Watkins, PhD, Cara Shirai, PhD, Terence M Myckatyn, MD, FACS, FRCSC

Aesthetic Surgery Journal, sjac282

Background: Breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy originating from the periprosthetic capsule of a textured, most often macrotextured, breast implant. Identified in women whose indications for breast implants can be either aesthetic or reconstructive, the genomic underpinnings of this disease are only beginning to be elucidated.

Objectives: The aim of this study was to evaluate the exomes, and in some cases the entire genome, of patients with BIA-ALCL. Specific attention was paid to copy number alterations, chromosomal translocations, and other genomic abnormalities overrepresented in patients with BIA-ALCL.  

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Sharadkumar Dicksheet, MD
Brooklyn, NY
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Dr. Dicksheet was a selfless humanitarian and philanthropist living on social security. He continued to give his time and expertise by providing thousands of cleft lip surgeries to children in need in India. Dr. Dicksheet passed away November 14, 2011.

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