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The Aesthetic Surgery Education and Research Foundation

Pro-Fibrotic CD26-Positive Fibroblasts Are Present in Greater Abundance in Breast Capsule Tissue of Irradiated Breasts Print

Mimi R. Borrelli, MBBS, MSc, BSc; Dre Irizzary, MD; Ronak A. Patel, BS; Dung Nguyen, MD; Arash Momeni, MD; Michael T. Longaker, MD; and Derrick C. Wan, MD

Aesthetic Surgery Journal  2020, Vol 40(4) 369–379

Background: Breast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified a fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression.

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