Adipose Stem Cell Function Maintained with Age: An Intra-Subject Study of Long-Term Cryopreserved Cells

Lauren E. Kokai, PhD; Dmitry O. Traktuev, PhD; Liyong Zhang, PhD; Stephanie Merfeld-Clauss, BS; Gabriella DiBernardo, BS; Hongyan Lu, PhD; Kacey G. Marra, PhD; Albert Donnenberg, PhD; Vera Donnenberg, PhD; E. Michael Meyer, BS; Peter B. Fodor, MD; Keith L. March, MD, PhD; and J. Peter Rubin, MD

Aesthetic Surgery Journal 2017, Vol 37(4) 454–463

Background:The progressive decline in tissue mechanical strength that occurs with aging is hypothesized to be due to a loss of resident stem cell number and function. As such, there is concern regarding use of autologous adult stem cell therapy in older patients. To abrogate this, many patients elect to cryopreserve the adipose stromal-vascular fraction (SVF) of lipoaspirate, which contains resident adipose stem cells (ASC). However, it is not clear yet if there is any clinical benefit from banking cells at a younger age.

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Dan Mills, MD
Laguna Beach, CA
Life Insurance Policy

“I give because my mentor, Rex Peterson, once said, ‘We should give back in the way that someone has given to us.’ My chosen profession has been good to me and by providing a gift to ASERF I am able to give back in a way that is long lasting and benefits our specialty as a whole.”