Pro-Fibrotic CD26-Positive Fibroblasts Are Present in Greater Abundance in Breast Capsule Tissue of Irradiated Breasts

Mimi R. Borrelli, MBBS, MSc, BSc; Dre Irizzary, MD; Ronak A. Patel, BS; Dung Nguyen, MD; Arash Momeni, MD; Michael T. Longaker, MD; and Derrick C. Wan, MD

Aesthetic Surgery Journal 2020, Vol 40(4) 369–379

Background: Breast capsular contracture is a major problem following implant-based breast reconstruction, particularly in the setting of radiation therapy. Recent work has identified a fibrogenic fibroblast subpopulation characterized by CD26 surface marker expression.

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Bahman Guyuron, MD
Lyndhurst, OH

“I give because plastic surgery is my passion and my business and the scientific studies supported through donations to ASERF work like Research and Development arm of any business; produce new and efficacious procedures and more importantly, assure patient safety”