Granzyme B Is a Biomarker for Suspicion of Malignant Seromas Around Breast Implants

Marshall E Kadin, MD, John Morgan, PhD, Haiying Xu, BS, Caroline Glicksman, MD, David Sieber, MD, William P Adams, Jr, MD, Pat McGuire, MD, Mark W Clemens, MD, Archana Thakur, PhD, Lawrence G Lum, MD, DSc

Aesthetic Surgery Journal, sjaa302

Background: Granzyme B (GrB) is a serine protease secreted, along with pore-forming perforin, by cytotoxic lymphocytes to mediate apoptosis in target cells. GrB has been detected in tumor cells associated with systemic and breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) but its potential use for detection of early BIA-ALCL has not been fully investigated.

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"I GIVE..."

Bahman Guyuron, MD
Lyndhurst, OH

“I give because plastic surgery is my passion and my business and the scientific studies supported through donations to ASERF work like Research and Development arm of any business; produce new and efficacious procedures and more importantly, assure patient safety”