Lauren E. Kokai, PhD; Dmitry O. Traktuev, PhD; Liyong Zhang, PhD;  Stephanie Merfeld-Clauss, BS; Gabriella DiBernardo, BS;  Hongyan Lu, PhD; Kacey G. Marra, PhD; Albert Donnenberg, PhD;  Vera Donnenberg, PhD; E. Michael Meyer, BS; Peter B. Fodor, MD;  Keith L. March, MD, PhD; and J. Peter Rubin, MD

Aesthetic Surgery Journal  2017, Vol 37(4) 454–463

Background:The progressive decline in tissue mechanical strength that occurs with aging is hypothesized to be due to a loss of resident stem cell number and function. As such, there is concern regarding use of autologous adult stem cell therapy in older patients. To abrogate this, many patients elect to cryopreserve the adipose stromal-vascular fraction (SVF) of lipoaspirate, which contains resident adipose stem cells (ASC). However, it is not clear yet if there is any clinical benefit from banking cells at a younger age.

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Marshall E. Kadin, MD; Anand Deva, MD; Haiying Xu, BS;John Morgan, PhD; Pranay Khare, PhD; Roderick A.F. MacLeod, PhD;Bruce W. Van Natta, MD; William P. Adams Jr., MD; Garry S. Brody, MD;and Alan L. Epstein, MD, PhD

Aesthetic Surgery Journal  2016, Vol 36(7) 773–781

Abstract: Almost 200 women worldwide have been diagnosed with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type strongly suggest an etio-pathologic link between breast implants and BIA-ALCL. It is postulated that chronic inflammation via bacterial infection may be an etiological factor. BIA-ALCL resembles primary cutaneous ALCL (pcALCL) in morphology, activated T-cell phenotype, and indolent clinical course. Gene expression array analysis,flow cytometry, and immunohistochemistry were used to study pcALCL and BIA-ALCL cell lines. Clinical samples were also studied to characterize transcription factor and cytokine profiles of tumor cells and surrounding lymphocytes. BIA-ALCL and pcALCL were found to have common expression of transcription factors SOCS3, JunB, SATB1, and a cytokine profile suggestive of a Th1 phenotype. Similar patterns were observed in a CD30+ cutaneous lymphoproliferative disorder (LPD). The patterns of cytokine and transcription factor expression suggest that BIA-ALCL is likely to arise from chronic bacterial antigen stimulation of T-cells. Further analysis of cytokine and transcription factor profiles may allow early detection and treatment of BIA-ALCL leading to better prognosis and survival.

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