The ASERF Scientific Research Committee and Board of Directors are pleased to announce the following grant award:

Researcher: Terence Myckatyn, MD

Grant Award: ASERF Interim Grant

Amount Awarded: $24,736.00

Project Name: Pilot study to identify a genetic predisposition to BIA-ALCL

Project Summary:

Specific Goal. To characterize somatic and germline mutations in a cohort of women who received en bloc capsulectomies for breast implant associated-anaplastic large cell lymphoma (BIA-ALCL) using whole exome sequencing (WES) and whole genome sequencing (WGS) approaches. Importantly, we already have tissue and blood for all the BIA-ALCL patients we propose to study in this proposal. These specimens are available for immediate analysis. We can have data in less than 6 months from initiation of funding.

Hypothesis. WGS of the capsulectomies containing BIA-ALCL and matched normals will identify genetic alterations that help better understand the somatic and germline drivers of this disease.