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Researcher: J. Peter Rubin, MD
Grant Award: ASERF Interim Grant
Amount Awarded: $65,000 Project Name: Clinical Adipose Stem Cell Banking: Is young better? Project Summary: Adult stem cells have the potential to transform plastic and reconstructive therapies and have been used to clinically enhance fat grafting, for skin rejuvenation, radiation injury, diabetic wound healing, ischemic neovacularization osseous tissue engineering, acute burn and other indication. Adipose tissue is an ideal source of stem cells (ASCs) that are capable of differentiating to multiple tissue types, potentially immunosuppressive, and capable of homing to damages tissue. ASCs are a very exciting stem cell population in a very exciting time of regenerative cell therapy discovery. Because of the large number of potential applications, patients may choose to bank ASCs at the time of elective liposuction procedures for future clinical use, with the premise that cells banked at a younger age will have superior function to older cells. To date, no study has ever examined biologic differences between banked stem cells freshly harvested from the same patient at a much later age(<10 years).We anticipate such data will be very high impact and will generate a highly relevant publication for plastic surgeons. Specific aim is to conduct a comparative pilot study of ASCs harvested and banked ten years ago to freshly harvested and banked ASCs. |
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Researcher: Terry Myckatyn, MD
Grant Award: ASERF Interim Grant
Amount Awarded: $52,900
Project Name: Impact on ADMs on Biofilms Around Breast Implants
Project Summary: The proposed study will evaluate the problem of capsular contracture in aesthetic breast surgery. Importantly, a cellular dermal matrices are being touted for their utility in revision aesthetic breast surgery and for their ability to limit capsular contracture. Claims related to reduced capsular contractures are based on modest animal data, and a scant few qualitative comments in the literature.
The goal is to establish whether a cellular dermal matrices impact periprosthetic biolfilm formation-a leading culprit in the putative mechanism for capsular contracture.
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Researcher: Jeffrey M. Kenkel, MD Grant Award: ASERF Interim Grant Amount Awarded: $28,874 Project Name: Effects of facial topical lidocaine on serum levels of lidocaine and MEG-X Project Summary: Topical lidocaine is applied liberally in clinics and spas throughout the world. Despite this, there is little to no data describing the safe doses, toxicity, and clinical guidelines regarding the topical use of lidocaine, particularly in a highly vascularized area such as the face. The primary purpose is to examine the metabolism of 4% topical lidocaine (LMX-4) to determine peak serum levels, and common clinical treatment variables affecting absorption, as a means of increasing patient safety. |
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