Skip to content

The Aesthetic Surgery Education and Research Foundation

Newsroom
Genomic Profiling to Understand the Pathogenesis of BIA-ALCL Print

The ASERF Scientific Research Committee and Board of Directors are pleased to announce the following grant award:

Researcher: Nandu Nair, MD

Grant Award: ASERF Interim Grant

Amount Awarded: $10,000

Project Name: Genomic Profiling to Understand the Pathogenesis of BIA-ALCL

Project Summary:
Hypothesis: We hypothesize that micro and nano-silica nanoparticles with polyurethane may differentially affect the induction of new biomarkers that can potentially influence the pathogenesis of BIA-ALCL. Accordingly, we propose following specific aim:  

Specific Aim: To study the comparative effect of nano, micro, and macro silica gel in combination with the polyurethane on global mRNA profiling in T-Cell. Hypothesis: a) silica and polyurethane is the basic implant materials; b) comparison of different sizes will reveal their physiological implications; c) The mRNA profiling will reveal novel yet unidentified molecular factors associated with the implant materials; d) identification of novel molecular markers specific to implant constituents may lead to better treatment approach in BIA-ALCL.

Significance: Currently more than 11 million women worldwide have breast implants and this number is continuously increasing. Recent reports of BIA-ALCL can be a significant health concern for women with implants. As such, examination of the molecular basis of BIA-ALCL may reveal specific biomarkers leading to better therapeutic approach.

 
Optimizing Breast Pocket Irrigation 3.0 2016 Print

The ASERF Scientific Research Committee and Board of Directors are pleased to announce the following grant award:

Researcher: Eric Culbertson, MD

Grant Award: ASERF Interim Grant

Amount Awarded: $3,953

Project Name: Optimizing Breast Pocket Irrigation 3.0 2016

Project Summary: Breast augmentation is the most commonly performed surgical cosmetic procedure in the United States and the world. The role of bacteria/biofilm on breast implant surfaces in potentiating the development of capsular contracture, one of the most common complications of breast augmentation, has been well established. Interestingly, there is strong data that chronic inflammation from bacteria/ biofilm is also responsible for the development of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). A higher burden of implant bacteria/biofilm is associated with greater lymphocyte stimulation, specifically a T-cell response. Chronic T-cell activation in response to the implant biofilm may be the inciting factor in BIA-ALCL. We have previously developed and demonstrated the efficacy of specific antibiotic irrigation solutions against bacteria commonly implicated implant infection, to be used at the time of implant placement. However, certain bacterial species known to cause implant infection and/or biofilm formation have not been tested, particularly gram negatives, and Ralstonia spp have recently been linked to BIA-ALCL. The purpose of this study is to compare the in vitro efficacy of povidone-iodine, two previously studied triple antibiotic solutions and three new antibiotic solutions against previously untested bacteria implicated in implant biofilm formation and/or linked to BIA-ALCL.

 
<< Start < Prev 1 2 3 4 5 6 7 8 9 10 Next > End >>

Page 6 of 26


Copyright © 2009-2018 ASERF. 11262 Monarch St., Garden Grove, CA 92841-1441 P: 800-364-2147 F: 562-799-1098